Matza, Louis S; Wyrwich, Kathleen W; Phillips, Glenn A; Murray, Lindsey T; Malley, Karen G ; и другие. Matza, Louis S; Wyrwich, Kathleen W; Phillips, Glenn A; Murray, Lindsey T; Malley, Karen G; Revicki, Dennis A. Quality of Life Research; Dordrecht Том 22, Изд. 2, (Mar 2013): 351-60. DOI:10.1007/s11136-012-0142-6
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Qual Life Res (2013) 22:351360 DOI 10.1007/s11136-012-0142-6
The Fatigue Associated with Depression Questionnaire (FAsD): responsiveness and responder denition
Louis S. Matza Kathleen W. Wyrwich
Glenn A. Phillips Lindsey T. Murray
Karen G. Malley Dennis A. Revicki
Accepted: 16 February 2012 / Published online: 9 March 2012 The Author(s) 2012. This article is published with open access at Springerlink.com
AbstractPurpose The Fatigue Associated with Depression Questionnaire (FAsD) was developed to assess fatigue and its impact among patients with depression. The purpose of this study was to examine the questionnaires responsiveness to change and identify a responder denition for interpretation of treatment-related changes.
Methods Data were collected at baseline and at 6 weeks from patients with depression starting treatment with a new antidepressant.
Results Of the 96 participants, 55.2% were women, with a mean age of 43.4 years. The total score and both sub-scales demonstrated statistically signicant change with moderate to large effect sizes (absolute values C0.76). FAsD change scores were signicantly correlated with change on the Brief Fatigue Inventory (r C 0.73; p \ 0.001). FAsD mean change scores discriminated among patient subgroups differing by degree of improvement in patient- and clinician-reported fatigue and depression. Responder denition for the two subscales and total score (0.67, 0.57, 0.62) was estimated primarily based on mean change among patients who reported a small but important improvement in fatigue.
Discussion The FAsD was responsive to change, and the responder denition may be used when interpreting treatment-related change. Results add to previous ndings suggesting the FAsD is a useful measure of fatigue among patients with depression.
Keywords Fatigue Depression Responsiveness
Responder denition Minimal important difference
Research on treatment of depression has increasingly focused on a symptom-specic approach, often targeting residual symptoms that persist after other symptoms have improved [16]. Residual symptoms have been shown to predict relapse of depressive episodes [4, 710], and they contribute to functional impairment even after other depressive symptoms have improved following pharmacological or psychological treatment [8, 9, 1113]. Much of the research on residual symptoms has focused on fatigue, which is one of the most common symptoms of major depressive disorder [1416]. Several studies suggest that fatigue is frequently a residual symptom, persisting in roughly 20 to 38% of patients who have remitted following.
